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Transcripts of Video ContentThe following are transcripts of the audio from interviews with Professor Eric Reynolds on the benefits of RECALDENT™ (CPP-ACP)
What exactly is RECALDENT™ (CPP-ACP)? RECALDENT™ (CPP-ACP) is a complex of amorphous calcium phosphate (which is a highly soluble calcium phosphate) which is stabilized by phosphopeptide derived from a milk protein casein; and this complex of the phosphopeptide and amorphous calcium phosphate, can repair early stages of tooth decay. How do peptides found in milk assist in the prevention of tooth decay? There's a lot of dental literature showing that milk consumption in animals and humans can prevent early stages of tooth decay. So we spent around 20 years investigating precisely what the component of milk was that was related to that activity, and we found it was related to this part of the protein, casein, that can stabilize calcium phosphate in this unique form of calcium phosphate, that can repair early stages of tooth decay. The National Institutes of Health, has discussed a need to move away from the "drill and fill" mentality to one of prevention of the disease processes. How does RECALDENT™ (CPP-ACP) fit with this position? There now certainly is a focus on prevention, preventive dentistry that is preventing disease before it develops, and also minimum intervention so where there's early stages of disease, trying to maintain as much of the tooth tissue as possible so if possible treating those early stages of disease so that it will arrest disease and actually even repair disease. Certainly fluorides are now known to arrest early stages of dental decay and can actually promote remineralization or repair of those early stages through salivary calcium phosphate. But one of the problems, certainly the rate limiting steps with that is, that there's not enough calcium phosphate in saliva to actively promote that, and this is where the RECALDENT™ (CPP-ACP) technology fits in very very well because it provides this soluble bioavailable form of calcium phosphate, that will repair the early stages of decay, certainly stop the caries process and repair early stages of decay, and acts in an additive way with fluoride so that you get a synergistic effect with fluoride. So it fits in very well with the preventive strategy. RECALDENT™ (CPP-ACP) is available in Gum and Mint Products. How long do you need to chew the gums/mints to have a beneficial effect on tooth remineralization? Our clinical trials using sugar free gum and sugar free mints with RECALDENT™ (CPP-ACP) have shown that if you use that product every day and in the trials we consumed the product 4 times a day, which for gum and for mint is considered normal consumption. So it was 4 times a day for a 2 week period, and in that 2 week period we got 20 to 30% of the mineral that had been lost from the tooth had been replaced, which was a very, very significant amount of mineral replacement in only a 2 week period. So it means that regular use of these products has the potential to significantly repair early stages of tooth decay. What other consumer products do you believe would be suitable for RECALDENT™ (CPP-ACP) to be included? I believe that RECALDENT™
(CPP-ACP) would be suitable for use in any product
that comes in contact with the tooth, so certainly consumer
products such as toothpaste and mouthwash would be ideal, particularly
because there is an additive effect between RECALDENT™
(CPP-ACP)
and fluoride, so for toothpaste that normally contains fluoride,
I think that's a very suitable vehicle for delivering RECALDENT™
(CPP-ACP)
with fluoride to get an additive effect. Beyond the consumer products, are there any dental applications and/or products in which you see a role for RECALDENT™ (CPP-ACP)? I believe that RECALDENT™ (CPP-ACP) does have a place in products that can be applied by dentists and dental hygienists and dental therapists. In particular products that can be applied directly to the teeth to prevent the development of tooth decay but also can be applied in a high concentrated form to actively repair the early stages of decay, and interestingly can also be added to restorative materials and we've got some exciting results showing that RECALDENT™ (CPP-ACP) is released from the restorative material, and can actually help prevent the development of tooth decay around that restorative material. As RECALDENT™ (CPP-ACP) is derived from milk, what advice would you give to people with milk allergies? People with lactose intolerance don't have to be concerned with RECALDENT™ (CPP-ACP) because RECALDENT™ (CPP-ACP) does not contain lactose so it's completely safe for people with lactose intolerance. It's also quite safe for people with a range of milk sensitivities. It's only people that should be careful and cautious of using the product are those people that have a true allergy to the milk protein casein. How do you see RECALDENT™ (CPP-ACP) fitting into a total oral care program? Sugar free gums and mints containing RECALDENT™ (CPP-ACP) can have a very important role to play in preventing tooth decay as part of the normal oral hygiene procedure. And that is using these products after meals and snacks to help prevent development of decay and even repair early stages of decay, but also after brushing your teeth, so that there's an interaction with fluoride and positive interaction with fluoride and even after leaving the dental surgery where there's been a professional application of fluoride to the teeth. Does RECALDENT™ (CPP-ACP) reduce/enhance the positive effects of flouride? We've shown now in a number of experiments that RECALDENT™ (CPP-ACP) works in a synergistic way with fluoride, it actually promotes the effect of fluoride by promoting the uptake and retention of fluoride on the tooth surface and also fluoride actually promotes the effect of RECALDENT™ (CPP-ACP) in repairing early stages of disease. So you end up with repaired early stages of disease with a fluoride form of tooth mineral which is actually more resistant to further acid challenge or further dental decay. So there's a significant additive effect between RECALDENT™ (CPP-ACP) and fluoride. There has been a lot of recent publicity around xylitol. Can the two products be used safely together? Xylitol is a sugar alcohol that can stimulate saliva and through the action of saliva can have beneficial effects on the teeth. But RECALDENT™ (CPP-ACP) is quite different to xylitol in that RECALDENT™ (CPP-ACP) will actually remineralize or repair teeth in its own right. So RECALDENT™ (CPP-ACP) is a form of calcium phosphate which is very soluble and available to the tooth structure to repair early stages of decay. So RECALDENT™ (CPP-ACP) and xylitol are quite different, however they are very compatible and many of the clinical studies that we have done in sugar free gum is adding RECALDENT™ (CPP-ACP) to a xylitol containing sugar free gum. Is RECALDENT™ (CPP-ACP) similar to Enamelon? Can the two be used together? RECALDENT™ (CPP-ACP) is quite different to Enamelon. Enamelon was an unstabilized calcium and phosphate that were added together and then applied to the teeth. The problem with that is that the calcium phosphate in not being stabilized precipitates out and then is not available to repair early stages of decay. So the major difference between RECALDENT™ (CPP-ACP) and Enamelon is that RECALDENT™ (CPP-ACP) has this phosphopeptide from milk, that not only stabilizes the calcium phosphate but actually delivers it to the tooth surface. To deliver a calcium phosphate in a highly available form that can repair early stages of tooth decay. How can dentists and hygienists influence the adoption of good oral care practices, which include products containing RECALDENT™ (CPP-ACP)? I believe that dentists, dental hygienists and dental therapists should advise their patients to use RECALDENT™ (CPP-ACP) products because of the significant effect and beneficial effect there is in helping to reduce tooth decay. So they should advise their patients to use these products after meals and snacks, and also after using standard oral hygiene procedures such as toothpaste and dental floss. |
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